This shop is for commercial customers only.
  • XELL Europe
  • XELL USA
Raw Material or Supplier Evaluation

Raw Material or Supplier Evaluation

Please contact us to get more details about this product.
  • 42
Within the last few decades cell culture media has evolved from complex serum or hydrolysate... more
Product information "Raw Material or Supplier Evaluation"

Within the last few decades cell culture media has evolved from complex serum or hydrolysate containing base formulations to chemically defined, animal component-free or animal origin-free, high performance cell culture solutions. In parallel, the biopharmaceutical industry has increased its expectation regarding lot-to-lot consistency and traceability. These requirements thrust analysis of contamination of cell culture media raw materials into focus. Collection of such data will not only aid in an understanding of current cell culture media characteristics, it will also provide required data to assess reasonably or maintain media performance.

With our key competences in medium development and manufacture, we know that not only raw materials (production, origin, quality), but also production technology are crucial factors influencing the quality of the final medium product. As a result, the same medium formulation can lead to deviating process performances. We therefore offer to test raw material sources and to compare different suppliers. Furthermore, we recommend respective biological testing of potential raw materials and evaluation of products from different suppliers with regard to process performance and production. Powder and liquid media characterization as well as solubility studies of your products are also part of our portfolio.

Please contact us to discuss your individual study requirements.

Feel free to read and download our case study on Raw material control: Trace element contaminations of amino acids. Since amino acids are a major component of cell culture media, which also make up a significant percentage of the media- and feed- composition, we show how raw materials for amino acids from different suppliers can have different trace element impurities.

Related links to "Raw Material or Supplier Evaluation"
Lot-to-lot testing Lot-to-lot testing
Lot-to-lot variation is a well-known effect in media production and can occur even in chemically defined media. It can be caused...
Cell Line Adaptation Cell Line Adaptation
Traditional mammalian cell culture is usually anchor-dependent and serum-supplemented, which is directly connected to a series of...
Cell Studies (stability, characterization) Cell Studies (stability, characterization)
With our broad range of analytical methods (cell growth, product quantification and qualification, flow cytometry applications), we...
Process Development and Optimization Process Development and Optimization
Process development such as feed strategy optimization can take up a lot of time and resources. With our long-standing experience...
AXP - dry powder manufacture AXP - dry powder manufacture
Accelerated Xell Production (AXP) - manufacture of customized dry powder formulations (Animal Origin Free only).  After...
CHO TF | Medium CHO TF | Medium
- Perfect medium for working with transient CHO cells - growth, transfection and production - CHO TF is a complete chemically...
Customized Medium and Feed Development Customized Medium and Feed Development
Xell offers targeted, rapid and efficient services for the development of custom cell culture medium and feed and is your ideal...
Medium and Feed Screenings/Benchmarkings Medium and Feed Screenings/Benchmarkings
Cell culture medium and feed selection typically involves screening and benchmarking of alternative off-the-shelf culture media...
AXP - liquid formulation production AXP - liquid formulation production
Accelerated Xell Production (AXP) - manufacture of customized liquid formulations (Animal Origin Free only). After production the...
Culture Media Analysis Bundle Culture Media Analysis Bundle
Spent media analysis is the analysis of the used media over the course of the production process and facilitates the selection of...
Basic Feed | Feed Basic Feed | Feed
- Single feeding solution optimzied for various cells and processes -  Basic Feed is a chemically defined , animal...
Hint!
CHOlean | Medium CHOlean | Medium
- Your lean and robust growth medium for various applications with unmatched pricing opportunities - CHOlean Medium is a...
TCX10D | Medium TCX10D | Medium
- The right choice for high-performance and long-term production with CHO GS cells - TCX10D Medium is a complete chemically...
TCX6D | Medium TCX6D | Medium
- Well performing medium for any CHO clone - flexible medium for stable production in batch or fed-batch processes - TCX6D...
HEK ViP NB | Medium HEK ViP NB | Medium
- Optimized virus production - best choice for transient expression in HEK cells - HEK ViP NB is a complete chemically defined...
TCX7D | Feed TCX7D | Feed
- The best option for fed-batch processes and in combination with TCX10D - for optimal nutrition of CHO GS cells - The TCX7D...
Hint!
HEK ViP NX | Medium HEK ViP NX | Medium
- Optimized virus production - best choice for transient expression in HEK cells - HEK ViP NX is a complete chemically defined...
Dry powder rehydration service Dry powder rehydration service
Rehydration of dry powder formulations (Animal Origin Free only). Rehydration within 10 business days after receipt of dry...
Consulting Consulting
Whether you are just starting to set up a cell culture lab, experiencing process limitations, seeing batch-to-batch variations of...
TC-42 w/o GF | Medium TC-42 w/o GF | Medium
- Optimal medium for various CHO processes - free of HT - TC-42 w/o GF is a complete chemically defined ,...
Trace Element Analysis Bundle for Spent Media Trace Element Analysis Bundle for Spent Media
Trace elements are determined by ICP-MS, combining highest sensitivity with excellent reliability, including: Element...
Amino acid Analysis Amino acid Analysis
With our amino acid measurement (order no. 103) free amino acids are measured, whereas with our total amino acid analysis (order...
HEK GM | Medium HEK GM | Medium
- Your best choice for stable expression with HEK cells - robust and effective - HEK GM is a complete chemically defined ,...
Hint!
Organic Acid Analysis - UHPLC based method Organic Acid Analysis - UHPLC based method
Organic acid content is determined using UHPLC-MS. Citric acid, Fumaric acid, Lactic acid, Malic acid, Pyruvat, Succinic acid,...
TC-42 w/ IGF | Medium TC-42 w/ IGF | Medium
- Optimal medium for various CHO processes - free of HT - TC-42 w/IGF is a complete chemically defined ,...
HEK TF | Medium HEK TF | Medium
- Well established transfection medium - ideal for production of recombinant proteins and antibodies - HEK TF is a complete...
Hint!
Polyamine Analysis Polyamine Analysis
Polyamine levels in mammalian cells play a key role in cells’ viability as well as protein synthesis. Knowing the polyamine content...
Dipeptide Analysis Dipeptide Analysis
UHPLC-MS/MS based measurement of dipeptides. Please contact us for more information.
Water-soluble Vitamin Analysis Water-soluble Vitamin Analysis
Our UHPLC-MS/MS method covers the following water-soluble vitamins, vitaminoids and precursors*: Vitamin B1: Thiamine...
MDXK Medium MDXK Medium
-Well performing and robust medium for high-density cultivation and production with MDCK and MDBK cells - MDXK Medium is a...
Hint!
HEK FS | Feed HEK FS | Feed
- Unique on the marked - Ideal boost for production of viral vectors, vaccines, proteins - HEK FS is a chemically defined ,...
Coulometric Karl-Fischer Titration Coulometric Karl-Fischer Titration
Determination of water content in solid and liquid samples using coulometric Karl-Fischer titration. Quantification range: 1 ppm...
Bioburden Testing Bioburden Testing
Determination of TAMC (total aerobic count) on TS-agar and for TYMC (total microbial count of yeasts) on SAB-agar is performed by...
Analysis of Total Amino Acid Content Analysis of Total Amino Acid Content
With our amino acid measurement (order no. 103) free amino acids are measured, whereas with our total amino acid analysis (order...
Antibody Quantification Antibody Quantification
Our HPLC method for quantification of antibodies is based on protein A affinity chromatography. If you are unsure whether your...
Glutathione Analysis Glutathione Analysis
UHPLC-MS/MS based measurement of glutathione (oxidized and reduced state). Please contact us for more information.
Hint!
Hybridoma Base Medium Hybridoma Base Medium
- Optimized for the demanding metabolism of Hybridoma cells and mAbs production - Hybridoma Base Medium is chemically defined...
Customized Analytical Method Development Customized Analytical Method Development
Xell offers targeted, rapid and efficient services for the development of custom analytical methods and is your ideal partner to...
qPCR-based Analysis qPCR-based Analysis
Analysis via qPCR (quantitative polymerase chain reaction) is extremely sensitive and can be utilized for detection of target...
Organic Acid Analysis - Colorimetric Assay Organic Acid Analysis - Colorimetric Assay
Organic acid content is determined using abcam colorimetric kits in combination with Thermo Fisher multimode plate reader...